Over-the-Counter (OTC) Eye Drops & Artificial Tears
A wide range of companies develop and market solutions for dry eyes, ranging from over-the-counter eye drops to advanced medical devices and prescription treatments. Below is a categorised overview of key players in the dry eye treatment market, based on product type:
1. Over-the-Counter (OTC) Eye Drops & Artificial Tears
These are typically the first-line treatment for dry eye symptoms.
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Alcon
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Products: Systane Ultra, Systane Complete, Systane Hydration
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Website: alcon.com
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Bausch + Lomb (Bausch Health Companies)
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Products: Soothe, Preservision, Retaine MGD (licensed via Ocusoft)
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Website: bausch.com
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Johnson & Johnson Vision (part of J&J MedTech)
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Products: Refresh Tears, Refresh Optive, Refresh Relieva
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Website: jjvision.com
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Allergan (a subsidiary of AbbVie)
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Products: Optive, Refresh Plus
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Note: Allergan previously owned the Refresh brand before J&J acquired it.
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Santen Pharmaceutical (Japan)
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Products: Soft Santear, Santen Tears, prescription options in Japan and Asia
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Website: santen.com
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2. Prescription Drugs for Chronic Dry Eye
These treatments are for moderate to severe dry eye disease, including inflammatory types.
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AbbVie (formerly Allergan)
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Product: Restasis (cyclosporine ophthalmic emulsion)
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Website: abbvie.com
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Sun Pharma
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Product: Cequa (cyclosporine 0.09%)
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Uses nanomicellar technology for better corneal penetration
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Website: sunpharma.com
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Novartis
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Product: Xiidra (lifitegrast 5%) — acquired from Takeda
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Targets inflammation associated with dry eye disease
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Website: novartis.com
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3. Medical Devices and In-Office Procedures
Used for more advanced treatment when drops or drugs are insufficient.
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Sight Sciences
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Product: TearCare® — a device-based therapy for Meibomian Gland Dysfunction (MGD)
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Website: sightsciences.com
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Alcon
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Product: iLux® MGD Thermal Pulsation System — targets gland blockages in the eyelids
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Website: alcon.com
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Johnson & Johnson Vision
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Product: LipiFlow® Thermal Pulsation System
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One of the leading FDA-approved treatments for MGD
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Website: jjvision.com
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Ocusoft
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Offers eyelid hygiene products like Ocusoft Lid Scrub, Retaine Flax, and Retaine PM
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Website: ocusoft.com
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4. Emerging and Niche Players
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Kala Pharmaceuticals – Eysuvis (loteprednol etabonate 0.25%) is a corticosteroid for short-term dry eye flares.
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Tarsus Pharmaceuticals – TP-03 for Demodex blepharitis, which can exacerbate dry eye symptoms.
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RegeneRx – Investigating thymosin beta-4 for ocular surface healing.
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Oyster Point Pharma (acquired by Viatris) – Tyrvaya (varenicline nasal spray), a novel approach stimulating tear production via nasal pathways.
5. Nutraceuticals and Supplements
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TheraTears (now part of Akorn) — Omega-3 supplements and dry eye nutrition products.
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PRN (Physician Recommended Nutriceuticals) — High-quality Omega-3s for MGD and inflammation.